Brain aging patterns in a large and diverse cohort of 49,482
WEBAug 15, 2024 · Large, diverse population studies enable identifying comprehensive and representative brain change patterns resulting from distinct but overlapping pathological and biological factors, revealing...
Harvard Aging Brain Study
WEBThe overall goal of the Harvard Aging Brain Study (HABS) is to elucidate the earliest changes in molecular, functional and structural imaging markers that signal the transition from normal cognition to progressive cognitive decline along the trajectory of preclinical Alzheimer’s Disease.
Imaging the aged brain: pertinence and methods - PMC
WEBMar 14, 2019 · Imaging methods ranging from optical imaging to magnetic resonance imaging (MRI) to newer technologies such as photoacoustic tomography each offer unique advantages and challenges in imaging the aged brain.
Brain and cognitive ageing: The present, and some predictions …
WEBFeb 26, 2022 · Here we discuss lessons for cognitive and brain ageing that have come from neuroimaging research (especially structural brain imaging), what neuroimaging still has left to teach us, and our views on possible ways forward in this multidisciplinary field.
Investigating nutrient biomarkers of healthy brain aging: a
WEBMay 21, 2024 · To assess brain health, a comprehensive battery of well-established cognitive and brain imaging measures was administered, along with 13 blood-based biomarkers of diet and nutrition. The...
Neuroimaging-derived brain age is associated with life ... - Nature
WEBJan 20, 2022 · In this cross-sectional study, to clarify the effects of mental health, as well as common metabolic factors (e.g., diabetes) on healthy brain aging in late life, we analyzed structural brain...
Imaging the aging brain: study design and baseline findings of …
WEBJun 26, 2020 · We here describe the study protocol and baseline findings of the SENIOR observational study which aim is the establishment of integrated, multiparametric maps of normal aging and the identification of early biomarkers for neurodegeneration.
Imaging the aging brain: study design and baseline findings of …
WEBJun 26, 2020 · Our multimodal protocol includes structural, diffusion, functional, and sodium magnetic resonance imaging (MRI) at 3 T and 7 T, positron emission tomography (PET), blood samples, genetics, audiometry, and neuropsychological and neurological examinations as well as assessment of neuronal risk factors.
MRI assessment of whole-brain structural changes in aging
WEBAug 9, 2017 · T2-FLAIR and T2*GRE improved the detection of white matter and microhemorrhage changes, enhancing the assessment. The study supports an automated BALI integration of multiple routine MRI scans, laying the groundwork for a future clinical tool to support brain aging diagnosis and intervention.
Functional MRI of brain physiology in aging and neurodegenerative ...
WEBFeb 15, 2019 · open access. Abstract. Brain aging and associated neurodegeneration constitute a major societal challenge as well as one for the neuroimaging community. A full understanding of the physiological mechanisms underlying neurodegeneration still eludes medical researchers, fuelling the development of in vivo neuroimaging markers.