Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis
WEBJul 28, 2017 — A variety of animal species exhibit pulmonary fibrosis conditions with characteristics similar to idiopathic pulmonary fibrosis (IPF) in humans. ILD has been studied as fibrosis occurs spontaneously in many animals, including West Highland Terriers, donkeys, cats, and horses.
Pulmonary fibrosis model of mice induced by different …
WEBMar 21, 2023 — The experimental use of BLM is to induce IPF animal models. It leads to lung patchy parenchymal inflammation, epithelial cell injury with reactive hyperplasia, epithelial-mesenchymal transition, activation and differentiation of fibroblasts to myofibroblasts, and basement membrane and alveolar epithelium injures [9].
Use of animal models in IPF research - PubMed
WEBIdiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with a poor prognosis and limited treatment options. Many compounds have shown efficacy in preclinical models of this condition, but only pirfenidone and nintedanib have been approved for clinical use.
A novel tree shrew model of pulmonary fibrosis - Nature
WEBAug 9, 2020 — Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease without effective therapy. Animal models effectively reproducing IPF disease features are needed to study the...
Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis
WEBJul 28, 2017 — Traditionally, preclinical trials have utilized mouse models of bleomycin (BLM)-induced pulmonary fibrosis-though several limitations prevent direct translation to human IPF. Spontaneous pulmonary fibrosis occurs in other animal species, including dogs, horses, donkeys, and cats.
A mouse model for IPF research | Lab Animal - Nature
WEBMay 27, 2020 — The new genetic model provides new insights into IPF pathophysiology and could be an important resource for the identification of biomarkers and therapeutic targets.
Animal Models of Fibrotic Lung Disease - PMC - National Center …
WEBFeb 28, 2013 — Attempts to understand the pathogenesis of IPF and other fibrotic lung disorders have relied on animal models. Unfortunately, no animal model exhibits progressive disease, and most animal models do not fully recapitulate the histologic pattern of UIP or other interstitial lung diseases.
The contribution of animal models to understanding the role of …
WEBJul 27, 2020 — Animal models of pulmonary fibrosis. Some domestic animals such as cats, dogs and horses can develop spontaneous pulmonary fibrosis, which share many of the histopathological features observed with human IPF.
WEBAbstract: Idiopathic pulmonary fibrosis (IPF) remains a disease with an unknown cause and a poor prognosis. Among attempts to define disease pathogenesis, animal models of experimental lung fibrosis have a prominent role. Commonly used models include exposure to bleo-mycin, silica, fluorescein isothiocyanate; irradiation; or expression of
Quantification of Lung Fibrosis in IPF-Like Mouse Model and ...
WEBJul 20, 2020 — The bleomycin (BLM)-induced pulmonary fibrosis mouse model is the most used and internationally recognized animal model (Jenkins et al., 2017). BLM has an important role in chemotherapy for the treatment of some forms of cancers, such as germinative tumors and Hodgkin’s lymphoma.