Endothelial to Mesenchymal Transition (EndoMT) in the …
WEBApr 11, 2016 · More recent studies, however, have demonstrated that another source of activated myofibroblasts in fibrotic diseases are endothelial cells (EC) that have acquired a mesenchymal phenotype through a process known as endothelial to mesenchymal transition (EndoMT).
Trajectory modeling of endothelial-to-mesenchymal transition …
WEBMar 26, 2021 · The endothelial-to-mesenchymal transition (EndMT) is an important source of fibrotic cells in idiopathic pulmonary fibrosis (IPF). However, how endothelial cells (ECs) are activated and...
Endothelial-to-mesenchymal transition: pathogenesis and …
WEBEndothelial-to-mesenchymal transition (EndoMT) is a process of transdifferentiation where endothelial cells gradually adopt the phenotypic characteristics of mesenchymal cells. This phenomenon was first discovered in embryonic heart development.
Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis ...
WEBMay 28, 2022 · IPF is a chronic, devastating, irreversible lung disease, characterized by injury-induced alveolar epithelial cell stress, progressive pathogenic myofibroblast differentiation, and imbalanced macrophage polarization, resulting in ECM deposition.
Endothelial to mesenchymal transition (EndMT) and arterial …
WEBWe now illustrate the role of EndMT in driving these changes. Methods: Immunohistochemical staining for VE-cadherin (VCad), N-cadherin (Ncad), S100A4, and vimentin (Vn) was performed on lung resections from …
Nintedanib Inhibits Endothelial Mesenchymal Transition in …
WEBJul 25, 2022 · Pulmonary fibroblasts play an important role in the development of IPF. Emerging evidence indicates that pulmonary endothelial cells could be the source of pulmonary fibroblasts through endothelial mesenchymal transition (EndoMT), which contributes to pulmonary fibrosis.
A Metabolic Basis for Endothelial-to-Mesenchymal Transition
WEBFeb 15, 2018 · Endothelial-to-mesenchymal transition (EndoMT) is a cellular process often initiated by the transforming growth factor β (TGF-β) family of ligands. Although required for normal heart valve development, deregulated EndoMT is linked to a wide range of pathological conditions.
Nintedanib Inhibits Endothelial Mesenchymal Transition in …
WEBJul 25, 2022 · In vitro EndoMT is promoted by IPF but inhibited by nintedanib. Representative IF staining images of VE-cadherin, α-SMA, and TGF-β in HPMECs treated with IPF serum (from patients with IPF) or nintedanib alone or in combination.
NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal
WEBOct 31, 2023 · The nucleotide-binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3) inflammasome and endothelial-to-mesenchymal transition (EndoMT) were shown to be involved in the pathogenesis of pulmonary fibrosis.
Endothelial to mesenchymal transition (EndMT) and vascular
WEBThe possibility of targeting EndMT as a therapeutic option in IPF is discussed. Expert opinion: With a steady increase in prevalence and mortality, IPF is no longer considered a rare disease.
Skip to content