Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case ...

Cells adjust the expansion and networking of their internal canal system as needed. A process known as ER-phagy (“ER-eating") ...

The ER-phagy receptor FAM134B is initially distributed via the membrane surface (left). Its IDRs move back and forth in a largely disordered manner, like tentacles. The formation of local clusters ...

Newly discovered mechanism helps detach and recycle parts of cellular canal membranes as needed – models developed using ...

The process of autophagy is a cell survival mechanism that occurs when the cell is under stress, via external environmental pressures, including the lack of nutrients, or via the internal ...

but the role of ER-phagy in viral replication process remains poorly understood. Here, the authors show Zika virus targets key ER-phagy receptor to inhibit ER-phagy process and physiologically ...