Uncovering the mechanisms behind T cell differentiation
T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response ...
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Research Reveals T Cell Differentiation Mechanisms
When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against ...
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Neuropeptides influence T cell differentiation during viral infections
T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 ...
Unveiling immune system responses that induce and maintain autoimmune pancreatitis
As a sufficient number of pDCs migrate into the inflamed pancreas, they produce CXCL9 and CXCL10 that attract CXCR3 + Th1 ...
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Corvus Pharmaceuticals Announces New Preclinical Data Highlighting Potential of Soquelitinib to Treat Systemic Sclerosis
The immunologic effects of soquelitinib lead to what is known as Th1 skewing and inhibition of Th2 and Th17 cells. Research on soquelitinib’s mechanism of action suggests that it has the potential to ...
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Hepatic Fibrosis -- Role of Hepatic Stellate Cell Activation
As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...
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Research spotlight: Uncovering the mechanisms behind T cell differentiation
Vijay K. Kuchroo, PhD, DVM, of the Gene Lay Institute of Immunology and Inflammation of Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School and the Ann Romney ...