Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Iñigo Rua-Figueroa, Natalia Pérez-Veiga, Esther Rodríguez-Almaraz, María Galindo-Izquierdo, Celia Erausquin, Antonio Fernandez-Nebro, Esther Uriarte Itzazelaia, Belén Serrano-Benavente, Jaime Calvo ...

Background Abnormalities of type I interferon signaling and production can initiate lupus development. Disturbances of nucleic acid-sensing molecules triggered autoreactivity in lupus mouse models.

Introduction Double-stranded-DNA antibodies (antiDNAds) are the most frequently detected serological markers in patients with Systemic Lupus Erythematosus (SLE). In clinical practice, it is usually ...

Several questions about SLE pathogenesis have continued to puzzle investigators over decades.A major question in the pathogenesis of SLE is the role of self-antigen. Early studies suggested that SLE ...

Background Pathogenic extrafollicular double negative 2 (DN2) B cells in SLE have a phenotype of IgD −CD27−Tbet+CD11c+, and are the precursor of ribonuclear protein (RNP) autoantibody producing B ...

Objective The heterogeneity of lupus clinical manifestations makes it difficult to precisely characterize the full spectrum of patient profiles with traditional real-life (claims) data sources. This ...

Purpose Tertiary lymphoid structures (TLS) are organized aggregation of immune cells at sites of inflammation. The development of TLS in autoimmune settings indicate that they may be sites for both ...

Background People with SLE (and their doctors) are concerned about the risk of COVID-19 infection, yet some patients still harbor concerns regarding vaccination. The first mRNA SARS-CoV-2 vaccines ...

Background SLE is an inflammatory condition associated with hyperactivation of the immune system, with mounting evidence that imbalances in the gut microbiota communities are common. These imbalances ...

Objective The objective of this review is to highlight the role of Neutrophil Extracellular Traps (NETs) in the pathogenesis of Systemic Lupus Erythematosus (SLE), focusing on their development, ...

Background Ultraviolet light (UV) is a known trigger of cutaneous lupus erythematosus (CLE) flares in systemic lupus erythematosus (SLE) patients, yet cell populations and mechanisms driving UV- ...