SANTA CLARA, Calif. — Never mind revenge. The 49ers are still trying to get over a massive Super Bowl hangover. Leave it to Patrick Mahomes and the Kansas City Chiefs to remind them of the task.

Instead, it was the San Francisco 49ers who held on to win, 30-24, in prime time. The 49ers trailed the Cowboys 10-6 at halftime but turned the tide in their favor with three straight touchdown ...

SAN FRANCISCO -- At long last, running back Dalvin Cook will make his Dallas Cowboys debut Sunday against the 49ers. Signed to the practice squad a week before the season started, Cook has waited ...

Kansas City Chiefs quarterback Patrick Mahomes scored his first rushing touchdown in 32 games last week in the Super Bowl rematch against the San Francisco 49ers. During that scamper from a yard ...

After last year's Super Bowl appearance, the San Francisco 49ers were projected as one of the best teams in the NFC. However, they are hurting just as badly as the Cowboys (3-3) since losing to ...

The wide receiver position has taken a significant hit for the San Francisco 49ers. Brandon Aiyuk will miss the remainder of the season with a torn ACL and MCL. Deebo Samuel was hospitalized on ...

The hits just keep on coming for the San Francisco 49ers. The team lost receiver Brandon Aiyuk in Sunday’s 28-18 loss to the Kansas City Chiefs to a torn ACL and MCL, and the number of players ...

The San Francisco 49ers could look for a Brandon Aiyuk replacement, and recent history suggests a Denver Broncos WR. Aiyuk tore his ACL and MCL in the Week 7 loss to the Kansas City Chiefs.

The San Francisco 49ers suffered a huge loss Week 7 against the Kansas City Chiefs, losing top wide receiver Brandon Aiyuk for the remainder of the season. The 49ers later confirmed that Aiyuk ...