These findings highlight midlife as a critical point for healthy brain aging and provide new insights into the molecular ...

Snapshot of a specialised nerve cell, called an interneuron, undergoing autophagy in the hippocampus - a key brain ... When damaged, they are removed through a recycling process called mitophagy, ...

Mitochondria play an essential role in maintaining cellular health. When damaged, they are removed through a recycling ...

New research highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process have been linked to ...

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood. Methods: This study ...