The San Francisco 49ers’ practice schedule began a day later than normal with a Monday night showdown against the Detroit Lions coming up in Week 17. Their practice report opened with some good news on the injury front. Running back Isaac Guerendo returned as a limited participant after missing all of Week 16 with a hamstring injury.

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury. From his impressive debut to becoming a key player in the 49ers’ backfield,

The rookie running back did not practice last week and has been officially ruled out of Sunday’s clash at Hard Rock stadium

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he ‘feels good,'” Adam Schefter of ESPN reported in a post shared on X, formerly Twitter.

The San Francisco 49ers face the Miami Dolphins this weekend and the rookie running back is now a major doubt to take part.

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, and Thursday will be no

The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update. The alternate running back appears to be on his way back,