gut.bmj1mon
CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
Caspase recruitment domain 9 (Card9), one of the IBD susceptibility ... function was assessed by an in vivo model of fungal infection and various functional assays, including endpoint dilution assay, ...
eLife1mon
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China Key Laboratory of Molecular ...
eLife10mon
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS
Binding of bacterial LPS to its cytosolic sensor, caspase-11 (Casp11), promotes Casp11 aggregation within a high-molecular-weight complex known as the noncanonical inflammasome, where it is activated ...