New research highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process have been linked to ...

These findings highlight midlife as a critical point for healthy brain aging and provide new insights into the molecular ...

Mitochondria play an essential role in maintaining cellular health. When damaged, they are removed through a recycling ...

Snapshot of a specialised nerve cell, called an interneuron, undergoing autophagy in the hippocampus - a key brain ... When damaged, they are removed through a recycling process called mitophagy, ...

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein ...

Research increasingly indicates that autophagy and its regulatory proteins can influence inflammation, programmed cell death, cell proliferation, and innate immune responses. Autophagy plays a vital ...

The processing of self-peptides in TECs depends on bulk protein degradation systems, specifically autophagy and proteasomes. Studies using autophagy- and proteasome-deficient mouse models have ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...