Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Input from the wider scientific community is essential to the work of the Committee on Key Non-Polar Destinations Across the Moon to Address Decadal-level Science Objectives with Human Explorers. The ...

The SH3 domains bind target proteins through amino-acid stretches containing prolines and hydrophobic amino acids. Arrows indicate the domains to which the interacting proteins bind.