The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway.

Background: Protein kinase C-β2 (PKCβ2) is a splice-variant of the PRKCB1 gene and belongs to a family of serine/threonine-specific kinases that are predominantly activated by diacylglycerol ...

Dip2 regulates PKC signalling through specific DAG acyl chain compositions—a crucial pathway, which emerged approximately 1.2 billion years ago, marking the advent of selective DAG-based signalling in ...

Xanthones can also influence protein kinase C (PKC) pathways, regulating ion channel activities on beta-cell membrane and subsequent insulin release.

(3) PMA experiments: Line 223-224: A major concern is related to the conclusion that "blood flow activates Notch in the cushion endocardium via the mTORC2-PKC signaling pathway". To make that claim, ...

Periventricular leukomalacia (PVL), the dominant cerebral white matter injury disease, is induced by hypoxia-ischemia and inflammation in premature infants. The activation of A adenosine receptor (AAR ...

Protein kinase C-ζ (PKC-ζ) is a serine/threonine kinase belonging to atypical protein kinase C (PKC) subfamily, and is activated by its phosphorylation. We and others have reported that PKC-ζ induced ...

In the present in silico research work, the presence of integral control in the protein kinase C ζ – insulin receptor substrate-1 (PKC ζ-IRS1) pathway is identified, verified mathematically and model ...

Protein kinase C (PKC), a phospholipid-dependent serine/threonine kinase, is widely expressed in the cardiovascular system. The change in PKC expression and activity represents an important biological ...

PKC, PKA, and PKG pathways control posttranslational regulation of receptor and channel proteins, and also have influences on gene expression.

PKC represents one of the major effectors downstream of GPCRs (especially Gq/11-coupled receptors). This led us to investigate whether PKC regulates the Hippo-YAP pathway.

A Adomeit, et al., Bradykinin B (2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor ...