The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway.

Background: Protein kinase C-β2 (PKCβ2) is a splice-variant of the PRKCB1 gene and belongs to a family of serine/threonine-specific kinases that are predominantly activated by diacylglycerol ...

Prostate-associated gene 4 (PAGE4) is a cancer/testis antigen that is typically restricted to the testicular germ cells but is aberrantly expressed in cancer. Furthermore, PAGE4 is developmentally ...

Advertising Feature: Application Note Published: April 2009 Visualizing signal transduction pathways by quantifying protein-protein interactions in native cells and tissue Simon Fredriksson Nature ...

α-Synuclein (α-Syn) aggregation is a hallmark of Parkinson’s disease and other neurodegenerative disorders. This study investigates the impact of controlled radical oxidation on α-Syn aggregation and ...

Although the function of the p42/p44 mitogen-activated protein (MAP) kinase pathway in long-term potentiation at hippocampal CA3–CA1 synapses has been well described, relatively little is known ...

Don’t use too much credit The second-largest factor in a credit report, accounting for 30%, is “ amounts owed.” That metric refers to credit utilization: how much of your available credit ...

That is, perhaps the β-PKC signaling pathway itself stimulates β-PKC transcription. In support of this idea, chronic α 1 -adrenergic stimulation in myocytes increases cPKC abundance 15 and induces ...