Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...

phosphoinositide 3-kinase (PI3K), sphingosine kinase (SphK), phospholipase C (PLC) and PLD function upstream of the activation of phospholipase A2 (PLA2), prostaglandin H2 synthase (PGH2S ...

Concerning melanoma, the skin areas exposed to UV radiation via sunlight accumulate many somatic mutations; characteristically, these are C to T transitions (Pfeifer et al., 2005). Most UV radiation ...

Here we identify transmembrane glycerophosphodiesterase GDE3 as a GPI-specific phospholipase C that cleaves and releases uPAR with consequent loss of function, whereas its homologue GDE2 fails to ...