BUFFALO, NY - March 25, 2025 – A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer." ...

TNFR deficiency did not affect neuroinflammation because there was no significant difference between the density of Iba1-positive microglia between STING ki;BL6 mice and STING ki;Tnfr1/2-/-mice . This ...

Despite expansion of resident cardiac stem cells (CSCs) after myocardial infarction (MI), the heart is unable to regenerate, suggesting that local factors inhibit CSC function. Tumor necrosis factor-α ...

BOSTON--(BUSINESS WIRE)--Boston Immune Technologies and Therapeutics, Inc. (BITT), a clinical stage developer of novel tumor necrosis factor superfamily receptor (TNFSR) antagonist antibodies ...

A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor- (TNF- ) and its receptors TNFR ...

The highly simplified Drosophila TNF-TNFR system, which consists of one TNF ligand, Eiger (Egr), and two TNFRs, Grindelwald (Grnd) and Wengen (Wgn), offers a powerful alternative for studying these ...

The highly simplified Drosophila TNF-TNFR system, which consists of one TNF ligand, Eiger (Egr), and two TNFRs, Grindelwald (Grnd) and Wengen (Wgn), offers a powerful alternative for studying these ...

Clinical data from trials testing bivalent TNFR agonist bivalent antibodies. A majority of synthetic TNF receptor agonists which entered clinical trials were IgG based monoclonal antibodies being ...

The FDA has cleared BITT’s IND application for a Phase I trial of BITT2101 (anti-TNFR2) in patients with relapsed/refractory Non-Hodgkin’s lymphomas ...

Cytokine mediators of muscle wasting include IL-6, which is a key regulator of skeletal muscle, IL-1, TNF, IFNγ, LIF, and TNF-related weak inducer of apoptosis (TWEAK; Fig 3). These factors signal ...

Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the ...