The cannabinoid agonist market is gaining momentum due to expanding medical cannabis legalization and growing clinical validation for its use in chro ...

Spicy food isn’t just about personal taste, it’s linked to physical and chemical processes in your body. The key ingredient ...

The compounds may work by interfering with TRPV1 receptors, which are responsible for detecting spice, potentially paving the way for milder-tasting spicy foods or spice-dampening condiments.

The compounds may work by interfering with TRPV1 receptors, which are responsible for detecting spice, potentially paving the way for milder-tasting spicy foods or spice-dampening condiments.

The researchers suspect the molecules interact with the TRPV1 receptor, which produces a sensation of burning pain when capsaicin binds to it.

Dubai-based Malini Nair’s 10-year-old is annoyed. His siblings devour spicy foods without a blink, but he struggles with ...

UB researchers have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain.

Investigators at the Jacobs School of Medicine and Biomedical Sciences have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain, which could open up new ...

These findings could lead to the development of new pain-relieving drugs that target this receptor. TRPV1 not only modulates pain but also protects against other stimuli.

There are more than 1,000 TRPV1 mutations in humans, and there's nothing novel about trying to switch the receptor off in order to relieve pain, but these attempts haven't been successful until now.

Spencer, Hu and colleagues reported on their findings, including experiments in mouse models of pain, in a paper in Neuron titled “ Piezo2 channels expressed by colon-innervating TRPV1-lineage ...