The Jaguars face the daunting task of traveling to the West Coast on the road to play the 49ers. Despite their 2024 record of 6-11, they still possess a formidable roster and coaching staff that has consistently competed at a high level. Jacksonville's inconsistencies on both sides of the ball continue, leading to another tough loss.

There appear to be two separate stretches on the Jacksonville Jaguars' 2025 schedule that could end up defining their season.