NFKB2 - Wikipedia
NFKB2 - Wikipedia. Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene. [5] Function. NF-κB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states.
The Nfkb1 and Nfkb2 Proteins p105 and p100 Function as ...
The Nfkb1 and Nfkb2 proteins, p105 and p100, have dual functions in the NF-κB signaling system. They are best known as precursors of p50 and p52. The rate of processing of the p105 and p100 regulates the availability of NF-κB dimers whose activity is regulated by IκB proteins.
NFKB2 Gene - GeneCards | NFKB2 Protein | NFKB2 Antibody
Oct 2, 2024 · NFKB2 (Nuclear Factor Kappa B Subunit 2) is a Protein Coding gene. Diseases associated with NFKB2 include Immunodeficiency, Common Variable, 10 and Common Variable Immunodeficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Cytosolic sensors of pathogen-associated DNA.
Signaling via the NFκB system - PMC - PubMed Central (PMC)
Another transcriptional target gene that is induced by nuclear NFκB activity is the nfkb2 gene, which produces the p100 protein. 4 p100 was first known as the precursor for the p52 protein, a dimerization partner of RelB and potentially other Rel proteins.
Q00653 - UniProt
The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing.
NFKB2 nuclear factor kappa B subunit 2 [ (human)] - National …
Data show that nuclear factor kappa B subunit 2 (NF-kappaB2) regulates intracellular cholesterol transport by controlling Niemann Pick type C2 protein (NPC2) expression. the mutant TERT promoter is reactivated by cooperative binding of p52 and ETS1.
Role of NF-kappaB2-p100 in regulatory T cell homeostasis ...
Sep 25, 2019 · Signals activating the non-canonical NF-κB pathway induce processing of the NF-κB precursor protein p100, encoded by Nfkb2, into the mature NF-κB2 subunit p52.
NFKB2 protein expression summary - The Human Protein Atlas
A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed. View primary data."
The noncanonical NFκB pathway: Regulatory mechanisms in …
Apr 18, 2024 · The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell survival, growth, maturation, and differentiation factors that are important for the development and maintenance of hematopoietic cells and immune organs.
Shaping the nuclear action of NF-κB - Nature
May 1, 2004 · A parallel non-classical pathway of REL protein activation has been identified that generates nuclear p52/RELB heterodimers.